{"product_id":"5-amino-1mq","title":"5 -Amino-1MQ Supplement | Support Cell Metabolism","description":"\u003ch3\u003e\u003cspan\u003eThe Science Behind 5-Amino-1MQ\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eNNMT plays a role in nicotinamide metabolism and methyl-group regulation, two processes connected to cellular energy balance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePreclinical studies have explored how inhibiting NNMT may influence:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul data-spread=\"false\"\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eNAD+ Metabolism:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Investigating the relationship between NNMT activity and cellular NAD+ availability.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eMetabolic Regulation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Examining pathways involved in energy storage and utilization.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eBody Composition:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Studying the effects of NNMT inhibition on adipose tissue and metabolic adaptation in animal models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eMuscle Function:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Exploring the relationship between NNMT activity, exercise adaptation, and muscle performance in aging animal models.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan\u003eWhy Researchers Are Interested\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eUnlike approaches focused on supplying additional NAD+ precursors, NNMT inhibition investigates how the body regulates the metabolism of nicotinamide already present within cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis distinction has made NNMT an emerging area of interest in metabolic and longevity research.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eBacked by Published Preclinical Research\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eScientific investigations have examined NNMT inhibition in relation to obesity-associated metabolic changes, dietary interventions, and muscle function.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThese findings provide a foundation for continued research, although human clinical benefits and long-term safety have not been established.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan\u003eExplore the Science of Metabolic Regulation\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eDiscover the emerging research surrounding NNMT and its role in cellular metabolism, energy regulation, and metabolic adaptation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eImportant:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e 5-Amino-1MQ is an investigational compound. Evidence discussed here comes from preclinical research and does not establish safety or effectiveness in humans. It is not FDA-approved to treat, prevent, or manage any disease.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-pm-slice=\"1 1 []\"\u003e\u003cstrong\u003e\u003cspan\u003eWe're excited to introduce this new frontier in metabolic \u0026amp; cellular energy research!\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eYour body's metabolic processes depend on a complex network of enzymes that influence how energy is produced, stored, and utilized.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOne enzyme gaining attention in metabolic research is \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003enicotinamide N-methyltransferase (NNMT)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e5-Amino-1MQ is a small-molecule NNMT inhibitor being investigated for its potential influence on cellular energy regulation, NAD+ metabolism, and metabolic signaling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReferences:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eKraus \u003c\/span\u003e\u003cspan\u003eD, \u003c\/span\u003e\u003cspan\u003eet \u003c\/span\u003e\u003cspan\u003eal. \u003c\/span\u003e\u003cspan\u003eNicotinamide N-methyltransferase knockdown protects against diet-induced obesity.\u003c\/span\u003e \u003cspan\u003eNature \u003c\/span\u003e\u003cspan\u003e(2014). \u003c\/span\u003e\u003cspan\u003ehttps:\/\/doi.org\/10.1038\/nature13198\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eNeelakantan \u003c\/span\u003e\u003cspan\u003eH, \u003c\/span\u003e\u003cspan\u003eet \u003c\/span\u003e\u003cspan\u003eal. \u003c\/span\u003e\u003cspan\u003eSelective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.\u003c\/span\u003e \u003cspan\u003eBiochemical \u003c\/span\u003e\u003cspan\u003ePharmacology \u003c\/span\u003e\u003cspan\u003e(2018). \u003c\/span\u003e\u003cspan\u003ehttps:\/\/pubmed.ncbi.nlm.nih.gov\/29155147\/\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eSampson \u003c\/span\u003e\u003cspan\u003eCM, \u003c\/span\u003e\u003cspan\u003eet \u003c\/span\u003e\u003cspan\u003eal. \u003c\/span\u003e\u003cspan\u003eCombined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice.\u003c\/span\u003e \u003cspan\u003eScientific \u003c\/span\u003e\u003cspan\u003eReports \u003c\/span\u003e\u003cspan\u003e(2021). \u003c\/span\u003e\u003cspan\u003ehttps:\/\/doi.org\/10.1038\/s41598-021-85051-6\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eDimet-Wiley \u003c\/span\u003e\u003cspan\u003eAL, \u003c\/span\u003e\u003cspan\u003eet \u003c\/span\u003e\u003cspan\u003eal. \u003c\/span\u003e\u003cspan\u003eNicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice.\u003c\/span\u003e \u003cspan\u003eScientific \u003c\/span\u003e\u003cspan\u003eReports \u003c\/span\u003e\u003cspan\u003e(2024). \u003c\/span\u003e\u003cspan\u003ehttps:\/\/doi.org\/10.1038\/s41598-024-66034-9\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NUBIOAGE","offers":[{"title":"Default Title","offer_id":44432867360846,"sku":null,"price":149.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0579\/5748\/2574\/files\/5amino1mqfront.png?v=1791480861","url":"https:\/\/store.theresurgeclinic.com\/products\/5-amino-1mq","provider":"The Resurge Clinic","version":"1.0","type":"link"}