{"product_id":"nad-300-cellular-health-healthy-aging","title":"NAD+ 300: Cellular Health + Healthy Aging","description":"\u003cp class=\"p2\"\u003eNAD+ 300 are professional-grade nutraceuticals designed to boost NAD+ and support healthy aging with nicotinamide riboside (NR), a specialized form of vitamin B3 that helps enhance cellular energy production and metabolic health\u003cspan class=\"s2\"\u003e1–5\u003c\/span\u003e*. NR is a precursor to NAD+, a molecule essential for energy production, mitochondrial function, and DNA repair. Each formula features Niagen®, the most studied form of NR, backed by over 35 published human clinical trials and trusted by leading researchers worldwide.\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003eBest for: \u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eSupports cellular function and healthy aging by promoting the production of cellular energy\u003cspan class=\"s2\"\u003e1-5 \u003c\/span\u003eand supporting efficient mitochondrial activity\u003cspan class=\"s2\"\u003e4,5,7–9\u003c\/span\u003e.*\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eProvides support for muscle health\u003cspan class=\"s2\"\u003e7,8\u003c\/span\u003e, brain health, and heart health** by promoting cellular energy production and overall metabolic health.*\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eNicotinamide riboside (NR) is a specialized form of vitamin B3 and a clinically studied precursor to NAD+, a coenzyme essential for cellular energy metabolism.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eShown in clinical studies to increase NAD+ levels in as little as two weeks, by up to 50% with 300 mg daily.\u003cspan class=\"s2\"\u003e10,11 \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eSeven clinical studies have shown a reduction in inflammatory markers with NR supplementation\u003cspan class=\"s2\"\u003e4,5,9,10,12–14 \u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p4\"\u003eComplements Biote’s hormone optimization protocols by delivering targeted cellular support for healthy aging, energy, and recovery.*\u003c\/p\u003e\n\u003cp class=\"p5\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003eIdeal for: \u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p3\"\u003ePeople who are already supporting hormones, sleep, and nutrition but still experience dips in energy, slower recovery, or signs of cellular stress. NAD+ 300 may help fill the gap by supporting cellular energy and function\u003cspan class=\"s2\"\u003e1-5\u003c\/span\u003e.*\u003c\/p\u003e\n\u003cp class=\"p3\"\u003ePatients focused on healthy aging, vitality, and resilience, especially those engaged in active lifestyles or experiencing increased physical or metabolic demands.*\u003c\/p\u003e\n\u003cp class=\"p4\"\u003eNAD+ levels may decline by up to 65% in adults between the ages of 30 and 70 (6,7) which can affect energy metabolism and cellular function over time.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s1\"\u003e \u003c\/span\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eSUGGESTED USE: \u003c\/b\u003e\u003c\/span\u003eTake 1 serving daily or as directed by your healthcare provider.\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eFREE FROM: \u003c\/b\u003e\u003c\/span\u003eFormulated without gluten and other common allergens.\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eWARNINGS: \u003c\/b\u003e\u003c\/span\u003eIf you are pregnant, nursing, or taking any medications, please seek the advice of a healthcare professional prior to use. Not intended for use by children under 18.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cspan class=\"s2\"\u003e\u003cb\u003eSTORAGE: \u003c\/b\u003e\u003c\/span\u003eStore tightly sealed in a cool, dry place.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e \u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eProduct Overview\u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003eNAD+ 300 are professional-grade nutraceuticals designed to support cellular energy and healthy aging. Each formula features nicotinamide riboside (NR), a specialized and clinically studied form of vitamin B3 that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme found in every cell.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003eNAD+ is involved in cellular energy production\u003cspan class=\"s1\"\u003e1-5\u003c\/span\u003e, mitochondrial function\u003cspan class=\"s1\"\u003e4,5,7-9\u003c\/span\u003e, and DNA repair\u003cspan class=\"s1\"\u003e6,15–17\u003c\/span\u003e. However, NAD+ levels decline significantly with age, by as much as 65% between ages 30 and 70\u003cspan class=\"s1\"\u003e6-7\u003c\/span\u003e, potentially impacting energy, metabolism, and overall cellular function. Supplementing with NR has been shown to efficiently and consistently increase NAD+ levels. Niagen® (NR) is efficiently taken up by cells and converted into NAD+, helping support the body’s natural energy production pathways.*\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eScientific References: \u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e1. Cuenoud, B. \u003ci\u003eet al. \u003c\/i\u003eBrain NAD Is Associated With ATP\u003c\/p\u003e\n\u003cp class=\"p2\"\u003eEnergy Production and Membrane Phospholipid\u003c\/p\u003e\n\u003cp class=\"p2\"\u003eTurnover in Humans. \u003ci\u003eFront Aging Neurosci \u003c\/i\u003e\u003cb\u003e12, \u003c\/b\u003e609517 (2020).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e2. Yang, Y. \u0026amp; Sauve, A. A. NAD+ metabolism:\u003c\/p\u003e\n\u003cp class=\"p2\"\u003eBioenergetics, signaling and manipulation for therapy. \u003ci\u003eBiochimica Et Biophysica Acta Bba - Proteins Proteom \u003c\/i\u003e\u003ci\u003e\u003c\/i\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003e1864, \u003c\/b\u003e1787–1800 (2016).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e3. Martens, C. R. \u003ci\u003eet al. \u003c\/i\u003eChronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. \u003ci\u003eNat. Commun. \u003c\/i\u003e\u003cb\u003e9, \u003c\/b\u003e1286 (2018).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e4. Zhou, B. \u003ci\u003eet al. \u003c\/i\u003eBoosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure. \u003ci\u003eJ. Clin. Investig. \u003c\/i\u003e\u003cb\u003e130, \u003c\/b\u003e6054–6063 (2020).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e5. Brakedal, B. \u003ci\u003eet al. \u003c\/i\u003eThe NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease. \u003ci\u003eCell Metab. \u003c\/i\u003e\u003cb\u003e34, \u003c\/b\u003e396-407.e6 (2022).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e6. Massudi, H. \u003ci\u003eet al. \u003c\/i\u003eAge-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. \u003ci\u003ePlos One \u003c\/i\u003e\u003cb\u003e7, \u003c\/b\u003ee42357 (2012).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e7. Janssens, G. E. \u003ci\u003eet al. \u003c\/i\u003eHealthy aging and muscle function are positively associated with NAD+ abundance in humans. \u003ci\u003eNat Aging \u003c\/i\u003e\u003cb\u003e2, \u003c\/b\u003e254–263 (2022).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e8. Lapatto, H. A. K. \u003ci\u003eet al. \u003c\/i\u003eNicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. \u003ci\u003eSci. Adv. \u003c\/i\u003e\u003cb\u003e9, \u003c\/b\u003eeadd5163 (2023).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e9. Wang, D. D. \u003ci\u003eet al. \u003c\/i\u003eSafety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction. \u003ci\u003eJACC: Basic Transl. Sci. \u003c\/i\u003e\u003cb\u003e7, \u003c\/b\u003e1183–1196 (2022).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e10. Elhassan, Y. S. \u003ci\u003eet al. \u003c\/i\u003eNicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. \u003ci\u003eCell Rep. \u003c\/i\u003e\u003cb\u003e28, \u003c\/b\u003e1717-1728.e6 (2019).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e11. Conze, D., Brenner, C. \u0026amp; Kruger, C. L. Safety and Metabolism of Long-term Administration of NIAGEN\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e(Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. \u003ci\u003eSci. Rep. \u003c\/i\u003e\u003cb\u003e9, \u003c\/b\u003e9772 (2019).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e12. Han, K. \u003ci\u003eet al. \u003c\/i\u003eBoosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects. \u003ci\u003eCell Rep. Med. \u003c\/i\u003e\u003cb\u003e4, \u003c\/b\u003e101157 (2023).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e13. Wu, J. \u003ci\u003eet al. \u003c\/i\u003eBoosting NAD+ blunts toll-like receptor-4 induced type-I interferon in control and systemic lupus erythematosus monocytes. \u003ci\u003eJ. Clin. Investig. \u003c\/i\u003e\u003cb\u003e132, \u003c\/b\u003ee139828 (2022).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e14. Remie, C. M. \u003ci\u003eet al. \u003c\/i\u003eNicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. \u003ci\u003eAm. J. Clin. Nutr. \u003c\/i\u003e\u003cb\u003e112, \u003c\/b\u003e413–426 (2020).\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e15. Airhart, S. E. \u003ci\u003eet al. \u003c\/i\u003eAn open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. \u003ci\u003ePLoS ONE \u003c\/i\u003e\u003cb\u003e12, \u003c\/b\u003ee0186459 (2017).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e16. Trammell, S. A., Yu, L., Redpath, P., Migaud, M. E. \u0026amp; Brenner, C. Nicotinamide Riboside Is a Major NAD+\u003c\/p\u003e\n\u003cp class=\"p2\"\u003ePrecursor Vitamin in Cow Milk. \u003ci\u003eJ Nutr \u003c\/i\u003e\u003cb\u003e146, \u003c\/b\u003e957–963 (2016).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e17. Nanga, R. P. R. et al. Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo. \u003ci\u003eMagn. Reson. Med. \u003c\/i\u003e\u003cb\u003e92, \u003c\/b\u003e2284–2293 (2024).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e18. Pencina, K. M. et al. MIB-626, an Oral Formulation of\u003c\/p\u003e\n\u003cp class=\"p2\"\u003ea Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults. \u003ci\u003eJ. Gerontol.: Ser. A \u003c\/i\u003e\u003cb\u003e78, \u003c\/b\u003e90–96 (2022).\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cspan class=\"s1\"\u003e \u003c\/span\u003e\u003cb\u003e*These statements have not been evaluated by the Food and Drug Administration. \u003c\/b\u003e\u003cb\u003e\u003c\/b\u003e\u003cb\u003eThis product is not intended to diagnose, treat, cure or prevent any disease. \u003c\/b\u003e\u003c\/p\u003e","brand":"BIOTE NUTRACEUTICALS","offers":[{"title":"Default Title","offer_id":43654908346446,"sku":"NAD+300Biote","price":48.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0579\/5748\/2574\/files\/NAD_300BottleImage.jpg?v=1776724390","url":"https:\/\/store.theresurgeclinic.com\/products\/nad-300-cellular-health-healthy-aging","provider":"The Resurge Clinic","version":"1.0","type":"link"}