5 -Amino-1MQ Supplement | Support Cell Metabolism

The Science Behind 5-Amino-1MQ

NNMT plays a role in nicotinamide metabolism and methyl-group regulation, two processes connected to cellular energy balance.

Preclinical studies have explored how inhibiting NNMT may influence:

• NAD+ Metabolism: Investigating the relationship between NNMT activity and cellular NAD+ availability.

• Metabolic Regulation: Examining pathways involved in energy storage and utilization.

• Body Composition: Studying the effects of NNMT inhibition on adipose tissue and metabolic adaptation in animal models.

• Muscle Function: Exploring the relationship between NNMT activity, exercise adaptation, and muscle performance in aging animal models.

Why Researchers Are Interested

Unlike approaches focused on supplying additional NAD+ precursors, NNMT inhibition investigates how the body regulates the metabolism of nicotinamide already present within cells.

This distinction has made NNMT an emerging area of interest in metabolic and longevity research.

Backed by Published Preclinical Research

Scientific investigations have examined NNMT inhibition in relation to obesity-associated metabolic changes, dietary interventions, and muscle function.

These findings provide a foundation for continued research, although human clinical benefits and long-term safety have not been established.

Explore the Science of Metabolic Regulation

Discover the emerging research surrounding NNMT and its role in cellular metabolism, energy regulation, and metabolic adaptation.

Important: 5-Amino-1MQ is an investigational compound. Evidence discussed here comes from preclinical research and does not establish safety or effectiveness in humans. It is not FDA-approved to treat, prevent, or manage any disease.

We're excited to introduce this new frontier in metabolic & cellular energy research!

Your body's metabolic processes depend on a complex network of enzymes that influence how energy is produced, stored, and utilized.

One enzyme gaining attention in metabolic research is nicotinamide N-methyltransferase (NNMT).

5-Amino-1MQ is a small-molecule NNMT inhibitor being investigated for its potential influence on cellular energy regulation, NAD+ metabolism, and metabolic signaling.

References:

• Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature (2014). https://doi.org/10.1038/nature13198

• Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology (2018). https://pubmed.ncbi.nlm.nih.gov/29155147/

• Sampson CM, et al. Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. Scientific Reports (2021). https://doi.org/10.1038/s41598-021-85051-6

• Dimet-Wiley AL, et al. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. Scientific Reports (2024). https://doi.org/10.1038/s41598-024-66034-9