NAD+ 300: Cellular Health + Healthy Aging

NAD+ 300 are professional-grade nutraceuticals designed to boost NAD+ and support healthy aging with nicotinamide riboside (NR), a specialized form of vitamin B3 that helps enhance cellular energy production and metabolic health1–5*. NR is a precursor to NAD+, a molecule essential for energy production, mitochondrial function, and DNA repair. Each formula features Niagen®, the most studied form of NR, backed by over 35 published human clinical trials and trusted by leading researchers worldwide.

Best for: 

Supports cellular function and healthy aging by promoting the production of cellular energy1-5 and supporting efficient mitochondrial activity4,5,7–9.*

Provides support for muscle health7,8, brain health, and heart health** by promoting cellular energy production and overall metabolic health.*

Nicotinamide riboside (NR) is a specialized form of vitamin B3 and a clinically studied precursor to NAD+, a coenzyme essential for cellular energy metabolism.

Shown in clinical studies to increase NAD+ levels in as little as two weeks, by up to 50% with 300 mg daily.10,11

Seven clinical studies have shown a reduction in inflammatory markers with NR supplementation4,5,9,10,12–14

Complements Biote’s hormone optimization protocols by delivering targeted cellular support for healthy aging, energy, and recovery.*

Ideal for: 

People who are already supporting hormones, sleep, and nutrition but still experience dips in energy, slower recovery, or signs of cellular stress. NAD+ 300 may help fill the gap by supporting cellular energy and function1-5.*

Patients focused on healthy aging, vitality, and resilience, especially those engaged in active lifestyles or experiencing increased physical or metabolic demands.*

NAD+ levels may decline by up to 65% in adults between the ages of 30 and 70 (6,7) which can affect energy metabolism and cellular function over time.

SUGGESTED USE: Take 1 serving daily or as directed by your healthcare provider.

FREE FROM: Formulated without gluten and other common allergens.

WARNINGS: If you are pregnant, nursing, or taking any medications, please seek the advice of a healthcare professional prior to use. Not intended for use by children under 18.

STORAGE: Store tightly sealed in a cool, dry place.

Product Overview

NAD+ 300 are professional-grade nutraceuticals designed to support cellular energy and healthy aging. Each formula features nicotinamide riboside (NR), a specialized and clinically studied form of vitamin B3 that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme found in every cell.

NAD+ is involved in cellular energy production1-5, mitochondrial function4,5,7-9, and DNA repair6,15–17. However, NAD+ levels decline significantly with age, by as much as 65% between ages 30 and 706-7, potentially impacting energy, metabolism, and overall cellular function. Supplementing with NR has been shown to efficiently and consistently increase NAD+ levels. Niagen® (NR) is efficiently taken up by cells and converted into NAD+, helping support the body’s natural energy production pathways.*

Scientific References:

1. Cuenoud, B. et al. Brain NAD Is Associated With ATP

Energy Production and Membrane Phospholipid

Turnover in Humans. Front Aging Neurosci 12, 609517 (2020).

2. Yang, Y. & Sauve, A. A. NAD+ metabolism:

Bioenergetics, signaling and manipulation for therapy. Biochimica Et Biophysica Acta Bba - Proteins Proteom

1864, 1787–1800 (2016).

3. Martens, C. R. et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat. Commun. 9, 1286 (2018).

4. Zhou, B. et al. Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure. J. Clin. Investig. 130, 6054–6063 (2020).

5. Brakedal, B. et al. The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease. Cell Metab. 34, 396-407.e6 (2022).

6. Massudi, H. et al. Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. Plos One 7, e42357 (2012).

7. Janssens, G. E. et al. Healthy aging and muscle function are positively associated with NAD+ abundance in humans. Nat Aging 2, 254–263 (2022).

8. Lapatto, H. A. K. et al. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Sci. Adv. 9, eadd5163 (2023).

9. Wang, D. D. et al. Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction. JACC: Basic Transl. Sci. 7, 1183–1196 (2022).

10. Elhassan, Y. S. et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. 28, 1717-1728.e6 (2019).

11. Conze, D., Brenner, C. & Kruger, C. L. Safety and Metabolism of Long-term Administration of NIAGEN

(Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults. Sci. Rep. 9, 9772 (2019).

12. Han, K. et al. Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects. Cell Rep. Med. 4, 101157 (2023).

13. Wu, J. et al. Boosting NAD+ blunts toll-like receptor-4 induced type-I interferon in control and systemic lupus erythematosus monocytes. J. Clin. Investig. 132, e139828 (2022).

14. Remie, C. M. et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am. J. Clin. Nutr. 112, 413–426 (2020).

15. Airhart, S. E. et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS ONE 12, e0186459 (2017).

16. Trammell, S. A., Yu, L., Redpath, P., Migaud, M. E. & Brenner, C. Nicotinamide Riboside Is a Major NAD+

Precursor Vitamin in Cow Milk. J Nutr 146, 957–963 (2016).

17. Nanga, R. P. R. et al. Acute nicotinamide riboside supplementation increases human cerebral NAD+ levels in vivo. Magn. Reson. Med. 92, 2284–2293 (2024).

18. Pencina, K. M. et al. MIB-626, an Oral Formulation of

a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults. J. Gerontol.: Ser. A 78, 90–96 (2022).

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.